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Hello,
I also think there is a real performance issue in the latest QuickFolders release.
Mozilla Thunderbird may now need up to 30 seconds displaying "Initializing QuickFolders" before becoming operational.

Cette critique concerne une version précédente du module (5.11). 

there are some problems with the folder iterator, in Thunderbird 102, we and Thunderbird Core are aware of the problem. see issue 283:
https://github.com/RealRaven2000/QuickFolders/issues/283

I recommend using the latest version from there to see if there is a difference.

there will be more improvements in QF code itself but I am also hoping that Mozilla will fix the caching issue reporred in bugs 1773822 and 1776280.