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Just click the right mouse button in a new e-mail and insert the signature.
First you have to create a signature (html or text - no file signaure!), if you would like to have no signature as default then choose "add signature from file" and leave the filename empty!
Now no signature is added by default and you have the option to add the signature by right-clicking.
If you need more than one signature please use Signature Switch addon!!